Membrane-associated Ion Pumps
نویسنده
چکیده
From the $Department of Pediatrics/Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, the **Department of Molecular Biology, Vanderbilt University, Nashville, Tennessee 37235, the 11 Veterans Administration Medical Center, Boise, Idaho 83702, the Department of Medicine, University of Washington, Seattle, Washington 98185, and the IIRoswell Park Memorial Institute, Buffalo, New York 14214
منابع مشابه
Cancer as a channelopathy: ion channels and pumps in tumor development and progression
Increasing evidence suggests that ion channels and pumps not only regulate membrane potential, ion homeostasis, and electric signaling in excitable cells but also play important roles in cell proliferation, migration, apoptosis and differentiation. Consistent with a role in cell signaling, channel proteins and ion pumps can form macromolecular complexes with growth factors, and cell adhesion an...
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– We study the time-dependent height fluctuations of an active membrane containing energy-dissipating pumps that drive the membrane out of equilibrium. Unlike previous investigations based on models that neglect either curvature couplings or random fluctuations in pump activities, our formulation explores two new models that take both of these effects into account. In the first model, the magni...
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Compared to ion pumps and carriers, ion channels have been quite late recognised as individual transport identities in red blood cells. Here the transition from cell population based flux experiments to single cell based patchclamp investigations are described in detail. The present knowledge of cation channels in red blood cells from their molecular identity to their electrophysiological prope...
متن کاملStructures of P-type and F-type ion pumps
P-type ion pumps are large, integral membrane proteins, whereas the F-type ATP synthase is an enormous multiple-subunit complex. Both have been the focal points of intensive physiological and mechanistic studies for many years; however, critical information about three-dimensional structure has been lacking. During the past year, new crystal forms of both P-type and F-type ATPases were reported...
متن کاملStructure-function relationship in P-type ATPases--a biophysical approach.
P-type ATPases are a large family of membrane proteins that perform active ion transport across biological membranes. In these proteins the energy-providing ATP hydrolysis is coupled to ion-transport that builds up or maintains the electrochemical potential gradients of one or two ion species across the membrane. P-type ATPases are found in virtually all eukaryotic cells and also in bacteria, a...
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